MEDICAL
Synergizing adoptive cell therapy: Boosting Cancer Cell Targeting with Dual TCR/CAR Engineering
Significance The T cell receptor (TCR) is a composite of multiple proteins with two main functions: antigen recognition (mediated by TCRα and TCRβ chains) and intracellular signaling (triggered by the CD3γ, CD3δ, CD3ε and CD3ζ chains) leading to...
Transmission of Alzheimer’s Disease Pathology through Bone Marrow Transplantation in a Preclinical Model
Significance Iatrogenic transmission refers to the unintended spread of a disease due to medical procedures or treatments. The concept of iatrogenic transmission in relation to Alzheimer’s disease (AD) involves a very specific and controversial hypothesis that certain medical...
Proteomic Profiling for Optimized Therapy Selection in Acute Myeloid Leukemia
Significance Acute Myeloid Leukemia (AML) is marked by the rapid proliferation of abnormal hematopoietic stem cells, leading to a high relapse rate despite initial treatment success. Traditional treatment has involved anthracyclines and cytosine arabinoside (AraC), known collectively as...
Identification and Functional Characterization of RAB32 Ser71Arg: A Novel Genetic Variant Implicated in Familial Parkinson’s Disease
Significance Parkinson’s disease (PD) is characterized as a progressive neurodegenerative disorder with symptoms including tremor, rigidity, and bradykinesia. The disease’s etiology is multifactorial, involving both environmental and genetic factors. Within the genetic domain, mutations in the LRRK2 gene...
Neural Circuitry and Neurochemical Modulation in Cognitive Function
Significance The hippocampus is primarily known for its role in forming and retrieving memories, particularly spatial and declarative memories. The prefrontal cortex, on the other hand, is crucial for higher cognitive functions such as planning, decision-making, and moderating...
Huge Amazon Sale of Never Pay the First Bill
Hi folks - Amazon dropped the price of the hardcover of my book, Never Pay the First Bill, to $9.50!That’s a 60% discount off the $24 list price. I’ve never seen it that low. I know some of...
Neural Circuitry and Neurochemical Modulation in Cognitive Function
Significance The hippocampus is primarily known for its role in forming and retrieving memories, particularly spatial and declarative memories. The prefrontal cortex, on the other hand, is crucial for higher cognitive functions such as planning, decision-making, and moderating...
Health Insurer Admits “Mistake” – and Still Sticks Disabled Veteran With $110,000 in Medical Bills
When companies make a mistake, they’re supposed to own it and make things right for the customer. When Blue Cross Blue Shield of Illinois made a big mistake, they stuck a disabled veteran with more than $110,000 in medical...
How Exercise Affects Digestion
Don’t go swimming after you eat. Avoid exercising on an empty stomach. Make sure you drink lots of water. You’ve probably heard these and other statements from your parents when you were young, a friend or even your...
GHz Frequency Microfluidics-Integrated CMOS Platform for Label-Free Cellular Dielectric Spectroscopy
Significance Label-free cell differentiation and sorting based on intrinsic physical properties of cells are essential techniques in cellular biology and medical research, which moves away from traditional methods that often require chemical dyes, antibodies, or genetic modification to...
